However, the chapters are full of time travel, but The 3rd Birthday still ends in December. The 3rd Birthday is also divided into six chapters and it is possible to play each chapter per day.

For The 3rd Birthday, it would also begin on December 24 like Parasite Eve.

However, Parasite Eve II is set over a span of four days and attempting to play Parasite Eve II in sync in real time is more difficult, as it could require three to five hours a day.

Subsequently, if a player wants to play the sequel Parasite Eve II, they could wait until the next September 4.

Parasite Eve is also popular among New Yorkers, for obvious reasons.

Day 6 is typically the shortest, and can be beaten in 40 minutes. Day 5 is typically the longest day, and is around three hours long, due to the long nature of the sewers and museum, so the player should find time on December 28. Usually, Days 1 to 4 tend to be an hour or two long. Usually, it becomes most popular on December 24 (as this is when Parasite Eve begins on Day 1) and ends on December 29 (Day 6), with the daily goal of playing each 'day' in the game per day. Playthroughs of Parasite Eve become popular in December, due to the setting of the game.Some claim that a 'No Liberate' run is how Parasite Eve should be played, although it is up to each player whether or not they should use Liberate. Some have praised the ability for making the final bosses easy for those who just want to complete the game ASAP so they can move onto the next game, or for those who never got the game's weapon/armor customization system - others note it can make the final bosses easy and ruin any challenge the final bosses provide. Near the end of the game, Aya will gain the Parasite Energy 'Liberate', which is known for being overpowered.

It could be seen as a brilliant commentary on superstition, or a mean joke. Some players get rid of them as soon as possible, while others keep them just in case. Due to the game's complicated code, no one has been able to datamine the game to see if they actually do anything, and there are rumors about the charms with some players saying it helps them get rare items and the like. Some players were annoyed by this, as the game never explicitly tells the player the use of the charms and they take up inventory space, and there is a debate whether or not they actually do anything (apart from the third being used to reserve one inventory slot for a story event).

During the game, Maeda gives Aya three 'good luck' charms.

It hasn't exactly aged well from low resolution, low quality character models, and the lack of voice acting except for grunts.

The mitochondria sound effects are generic and sound like squirrel or chipmunk noises.

The music is reused often and can get annoying.